Obesity induces neuroinflammation mediated by altered expression of the renin-angiotensin system in mouse forebrain nuclei. (AT1a) receptor for these responses by using the Cre/lox system in mice to selectively delete the AT1a receptor from the PVN. Relative gene expression in the PVN of the PVN AT1a KO mouse (n = 8) and controls (n = 9 Cited by: 31. In rodents, two AT1 receptor subtypes, AT1A and AT1B, have been isolated. Using specific riboprobes forin situhybridization histochemistry, recent studies mapped the distribution of AT1A, AT1B, and AT2 receptor mRNAs in the adult rat and found a predominant expression of AT1A and AT2 mRNA in the brain and of AT1B in the pituitary. Very limited Cited by: 394.
Distribution of angiotensin type-1 receptor messenger RNA expression in the adult rat brain. the aim of the present study was to establish the precise anatomical localization of cells synthetizing the AT1A receptor in the adult rat brain. High AT1A messenger RNA expression was found in the vascular organ of the lamina terminalis, the median Cited by: 159. Though, its expression declines after birth, it is expressed at low levels in the normal adult cardiovascular system, adrenal gland, kidney, brain, uterine myometrium and skin. AT2 receptor Knock-out (KO) mouse shows higher blood pressure than wild type animals without any growth abnormalities.Cited by: 18.
Interacting molecule of AT1 receptor, ATRAP, is colocalized with AT1 receptor in the mouse renal tubules Y Tsurumi1, K Tamura1, Y Tanaka1, Y Koide1, M Sakai1, M Yabana1, Y Noda2, T Hashimoto1, M Kihara1, N Hirawa1, Y Toya1, Y Kiuchi2, M Iwai3, M Horiuchi3 and S Umemura1 1Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, . (C) Northern blot analysis for AT1A mRNA. 20 mg of each total RNA from the two adult mice (F 2 generation) were loaded in each lane and probed with a mouse AT1A-specific probe (upper row), and then, after stripping, a glyceraldehyde 3-phosphate dehydrogenase probe (lower row). Ba, BamHI; PMC1-tk and PGK-tk, negative selection genes.
In rodents, two AT1 receptor subtypes, AT1A and AT1B, have been isolated. Using specific riboprobes for in situ hybridization histochemistry, recent studies mapped the distribution of AT1A, AT1B, and AT2 receptor mRNAs in the adult rat and found a predominant expression of AT1A and AT2 mRNA in the brain and of AT1B in the pituitary. A major role for AT receptor in mouse mesenteric resistance vessels and its distribution in heart and neuroendocrine tissues distribution of AT1b receptor mRNA with AT1a receptor mRNA in the.